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Systolic function is conveniently (although not always accurately) measured as the ejection fraction (EF), calculated as stroke volume divided by end-diastolic volume. 1 The LV EF is easily interpreted. The lower limit of normal is ≈50%. The lower the EF is, the greater the reduction in systolic function.
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VA-ECMO reduces right atrial pressure, decongesting the liver and kidneys. Mean aortic pressure rises, increasing afterload; if the LV is unable to overcome the increased afterload, stroke volume falls, resulting in loss of aortic pulsatility and stagnation of blood, potentiating thrombus formation.
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